Antibiotics and antimicrobial therapy news and reviews
Azithromycin information
Instruction for use characterizes this drug as a broad-spectrum antibacterial drug.

Azithromycin belongs to azalides (sub-group of macrolide antibiotics). Unlike Erythromycin (classic macrolide), azalides has slightly changed chemical structure, which allowed to broaden the scope of their antibacterial activity and increase their acid resistance and ability of drug active substances to get inside the cells. Therefore, some intracellular infections, such as treponema, ureaplasma, mycoplasmas, chlamydia and spirochete Borrelia are especially sensitive to this antibitotic. At that, it is possible to achieve high concentration of drug in the inflamed area.

As this medicine is in great demand, pharmaceutical companies release the drug in different dosage forms. For oral intake, you can buy Azithromycin in pills and capsules, powder and granules for dissolution in the water. If you prefer injections, you should choose ampoules.

Due to the high acid resistance, antibiotic is rapidly absorbed into the blood from the intestine, easily penetrates into the soft tissues, skin, digestive- and respiratory organs system. The maximum concentration of drug in the blood plasma is achieved 3 hours after the intake, while the microbicidal effect of the drug lasts for a week.

Indications for the use of Azithromycin

Infectious diseases, caused by the gram-positive and gram-negative bacteria and some kinds of anaerobic microorganisms. These pathologies include the infections of skin (impetigo, erysipelas), urinary tract (cystitis) and respiratory system (sinusitis, bronchitis, tonsillitis and pharyngitis). Gastroenterologists use this antibiotic to suppress the activity of Helicobacter pylori as a part of combination therapy during the treatment of peptic and duodenal ulcer. The drug also proved to be very effective in the combined therapy of pneumonia.

The dosage and duration of treatment course must be defined by your doctor depending on the character and severity of infectious disease. The dosage can reach both 250 and 1000 mg a day. The duration of treatment is 3 – 7 days. In case of severe diseases (for example, pneumonia), doctors prescribe intravenous injections in the first two days of treatment process. After that, you should change them for capsules or pills.

As any antibacterial drugs, Azithromycin has its contraindications, which must be considered during the prescription. It is not recommended to use this drug in case of intolerance to its components. You should refuse from the treatment with this antibiotic, if you suffer from kidney or renal failure. The intake of this medicine is contraindicated to the pregnant and lactating women and the children under 16.

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